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    Chief Minister Shri Bhupendra Patel has become popular among the people for his simplicity and spontaneity along with his soft-spoken, firm leadership. The villagers of Giyod in Gandhinagar district experienced similar simplicity and spontaneity on Tuesday morning.  Chief Minister Shri Bhupendra Patel reached Giyod village without informing anyone in the village about any pre-arranged program. He reached Giyod village and instinctively inquired about the cleanliness, schooling, etc. of the village elders.  Shri Bhupendra Patel made his impression as Bhupendra ‘Dada’ brighter by interacting with these children by going among the forgotten children of Giyod village. The Chief Minister also met the women of the village. He enjoyed the tea while interacting with the villagers.  Chief Minister Shri Bhupendra Patel went as per schedule to Kantharpur on Tuesday morning to inspect the ongoing development works as a pilgrimage destination of Mahakali Vad. He suddenly instructed his security officials to take the vehicles to Giyod village and reached Giyod directly without any pre-arranged schedule. The villagers of Giyod, the children were pleasantly surprised to see the Chief Minister ambushed in their village.  The Chief Minister was accompanied by Chief Secretary Shri Pankaj Kumar, Gandhinagar District Collector Shri Kuldeep Arya and others.

    Chief Minister Shri Bhupendra Patel has become popular among the people for his simplicity and spontaneity along with his soft-spoken, firm leadership. The villagers of Giyod in Gandhinagar district experienced similar simplicity and spontaneity on Tuesday morning. Chief Minister Shri Bhupendra Patel reached Giyod village without informing anyone in the village about any pre-arranged program. He reached Giyod village and instinctively inquired about the cleanliness, schooling, etc. of the village elders. Shri Bhupendra Patel made his impression as Bhupendra ‘Dada’ brighter by interacting with these children by going among the forgotten children of Giyod village. The Chief Minister also met the women of the village. He enjoyed the tea while interacting with the villagers. Chief Minister Shri Bhupendra Patel went as per schedule to Kantharpur on Tuesday morning to inspect the ongoing development works as a pilgrimage destination of Mahakali Vad. He suddenly instructed his security officials to take the vehicles to Giyod village and reached Giyod directly without any pre-arranged schedule. The villagers of Giyod, the children were pleasantly surprised to see the Chief Minister ambushed in their village. The Chief Minister was accompanied by Chief Secretary Shri Pankaj Kumar, Gandhinagar District Collector Shri Kuldeep Arya and others.

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    Know Why Sant Surdas Had Asked Lord Krishna For The Boon Of Blindness

    Know Why Sant Surdas Had Asked Lord Krishna For The Boon Of Blindness

    Australian High Commissioner Calls On Punjab C M Bhagwant Mann

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    Why Our Children Are Loosing Their Smiles ?

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    BLive Expands EV Store Network in City with its Third Store in Hyderabad

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    8 Probationary IAS officers of the state’s 2020-22 batch pays courtesy visit to Guj CM

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    Gujarat Chief Minister pays surprise visit to Giyod village in Gandhinagar

    Gujarat Chief Minister pays surprise visit to Giyod village in Gandhinagar

    Chief Minister Shri Bhupendra Patel has become popular among the people for his simplicity and spontaneity along with his soft-spoken, firm leadership. The villagers of Giyod in Gandhinagar district experienced similar simplicity and spontaneity on Tuesday morning.  Chief Minister Shri Bhupendra Patel reached Giyod village without informing anyone in the village about any pre-arranged program. He reached Giyod village and instinctively inquired about the cleanliness, schooling, etc. of the village elders.  Shri Bhupendra Patel made his impression as Bhupendra ‘Dada’ brighter by interacting with these children by going among the forgotten children of Giyod village. The Chief Minister also met the women of the village. He enjoyed the tea while interacting with the villagers.  Chief Minister Shri Bhupendra Patel went as per schedule to Kantharpur on Tuesday morning to inspect the ongoing development works as a pilgrimage destination of Mahakali Vad. He suddenly instructed his security officials to take the vehicles to Giyod village and reached Giyod directly without any pre-arranged schedule. The villagers of Giyod, the children were pleasantly surprised to see the Chief Minister ambushed in their village.  The Chief Minister was accompanied by Chief Secretary Shri Pankaj Kumar, Gandhinagar District Collector Shri Kuldeep Arya and others.

    Chief Minister Shri Bhupendra Patel has become popular among the people for his simplicity and spontaneity along with his soft-spoken, firm leadership. The villagers of Giyod in Gandhinagar district experienced similar simplicity and spontaneity on Tuesday morning. Chief Minister Shri Bhupendra Patel reached Giyod village without informing anyone in the village about any pre-arranged program. He reached Giyod village and instinctively inquired about the cleanliness, schooling, etc. of the village elders. Shri Bhupendra Patel made his impression as Bhupendra ‘Dada’ brighter by interacting with these children by going among the forgotten children of Giyod village. The Chief Minister also met the women of the village. He enjoyed the tea while interacting with the villagers. Chief Minister Shri Bhupendra Patel went as per schedule to Kantharpur on Tuesday morning to inspect the ongoing development works as a pilgrimage destination of Mahakali Vad. He suddenly instructed his security officials to take the vehicles to Giyod village and reached Giyod directly without any pre-arranged schedule. The villagers of Giyod, the children were pleasantly surprised to see the Chief Minister ambushed in their village. The Chief Minister was accompanied by Chief Secretary Shri Pankaj Kumar, Gandhinagar District Collector Shri Kuldeep Arya and others.

    The Prime Minister of the UK Mr. Boris Johnson on a visit to the world famous Akshardham in Gandhinagar

    The Prime Minister of the UK Mr. Boris Johnson on a visit to the world famous Akshardham in Gandhinagar

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    Union Bank of India Financial Results for the Quarter and Year ended March 31, 2022

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Recently published data on Favipiravir as treatment for mild to moderate COVID-19 demonstrates significant improvement in time to clinical cure

NewsMonks by NewsMonks
1 year ago
in Health & Fitness
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Uttar Pradesh establishes Integrated COVID Control & Command Centre, and a Unified State COVID Portal
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These findings were observed in a Phase 3 clinical trial conducted by Glenmark Pharmaceuticals and has been published by the globally reputed, peer reviewed International Journal of Infectious Diseases.

The oral antiviral medication Favipiravir, that prevents the replication phase of the virus life-cycle, leads to significant improvement in clinical cure in patients with mild to moderate COVID-19. These findings were observed in a randomized, controlled Phase 3 clinical study conducted by Glenmark Pharmaceuticals, and the results are now published online in The International Journal of Infectious Diseases (IJID). The IJID is a globally reputed, peer-reviewed, pubmed indexed, open access journal published monthly by the International Society for Infectious Diseases, USA. The published findings will also appear in the print edition of the journal in the coming weeks.

Dr Zarir F. Udwadia. MD, FRCP, FCCP, Breach Candy Hospital, Mumbai commented “Every claim for the efficacy of a new drug in COVID-19 must be backed by evidence from a clinical trial. Glenmark has done just that with Favipiravir. Their well-designed trial in 150 patients showed Favipiravir resulted in a significantly improved time to clinical cure and rapid viral clearance. Based on this I would consider the use of this anti-viral drug in symptomatic patients with mild to moderate COVID-19. I eagerly await the results of similar trials presently being conducted in Boston and at Stanford”. 

Mr. Robert Crockart, Chief Commercial Officer Glenmark Pharmaceuticals said, “From the first reported case of COVID-19, our every effort was to bring a viable, safe and effective treatment option to patients in a timely manner. It is encouraging to see our trial results now published in a reputed global medical journal, which we hope will support other countries in their fight against this disease.”

“The study, which was undertaken by Glenmark Pharmaceuticals, at a time when the number of cases for infections were dramatically increasing around the globe, demonstrates Glenmark’s commitment to ensuring all patients have access to affordable medication, to make a positive impact on their quality of life,” said Dr. Monika Tandon, Sr. Vice President & Head – Clinical Development, Global Specialty/Branded Portfolio at Glenmark.

The publication on the study titled “Efficacy and Safety of Favipiravir, an Oral RNA-Dependent RNA Polymerase Inhibitor, in Mild-to-Moderate COVID-19:  A Randomized, Comparative, Open-Label, Multicenter, Phase 3 Clinical Trial” was authored by Dr. Zarir .F. Udwadiaand other co-authors .

The link to the article is mentioned below

https://authors.elsevier.com/sd/article/S1201-9712(20)32453-X

The Phase 3 study with antiviral drug Favipiravir, brand name FabiFlu®, was conducted in 150 patients as part of a randomised, open label, multicenter, Phase 3 study. The study aimed to evaluate the efficacy and safety of Favipiravir plus standard supportive care (Favipiravir treatment arm), versus standard supportive care alone (control arm), in mild to moderate patients, randomized within a 48 hour window of testing RT-PCR positive for COVID-19.

Favipiravir was found to provide multiple treatment benefits, demonstrated by faster time to clinical cure, and significantly delayed the need for supportive oxygen therapy. Additionally, patients of confirmed COVID-19 with moderate symptoms were discharged from hospital earlier than those patients that did not receive Favipiravir, with the median time to clinical cure reduced by 2.5 days compared with the control group.

Since it was first pronounced a pandemic by the WHO in March, COVID-19 has continued to impact the lives of millions of people globally. As of date, over 50 mn. cases have been reported, with over 1 mn. deaths attributed to this disease. The virus has reportedly spread to all around the world and territories across the globe. Most disease cases are mild to moderate, with symptoms including fever, cough and breathlessness. In severe cases, COVID-19 can cause pneumonia, severe acute respiratory syndrome, kidney failure and death.

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Favipiravir is an antiviral medication that works by inhibiting a viral enzyme called RdRP (RNA dependent RNA polymerase), thereby halting the virus’s replication cycle. This helps control the multiplication of the virus and prevents its spread in the patient. This mechanism of action of Favipiravir is novel compared to most antivirals that primarily prevent entry and exit of the virus from cells. Several published reports are now available of the drug’s effectiveness against COVID-19.

Patients in the Glenmark clinical trial received Favipiravir tablets 3,600 mg (1,800 mg BID) (Day 1) + 1,600 mg (800 mg BID) (Day 2 or later) for up to maximum of 14 days, along with standard supportive care. Randomization was stratified based on disease severity into mild and moderate. Favipiravir was well tolerated with no serious adverse events (SAEs) or deaths in the Favipiravir treated arm. The pre-specified primary endpoint, time from randomisation to cessation of oral shedding of the SARS-CoV-2 virus, demonstrated a 2 day earlier virological cure in the Favipiravir treatment group, though not statistically significant. However, significant improvement in time to clinical cure and other secondary end-points suggest Favipiravir may be beneficial in the treatment of mild-to-moderate COVID-19.  In June 2020, Glenmark received manufacturing and marketing approval from India’s drug regulator for Favipiravir (FabiFlu®), making it the first oral approved medication in India for the treatment of mild to moderate COVID-19. The manufacturing and marketing approval was granted as part of an accelerated approval process, considering the emergency situation of the COVID-19 outbreak in India. The approval’s restricted use entails responsible medication use where every patient must have signed informed consent before treatment initiation.

Tags: covidCovid 19Favipiravir
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